Chronic stress exposure increases diabetes incidence and alters gut microbiota in nod/shiltj mice

RUBINSTEIN MR; WYDRA LS; BIANCHI MS; WALD MR; GENARO AM

Mar del Plata

Congreso; Reunión de Sociedades de Biociencias; 2022

SAIC, SAI, SAFIS, FAIC

Type 1 diabetes (T1D) is characterized by impaired insulin secretionand it has been recognized the contribution of psychosocial factors(including chronic stress exposure) in T1D. Gut microbiota is thegroup of microorganisms (commensal, symbiotic and pathogenic)that we find in our gut. It participates in multiple functions and anassociation between unbalanced microbiota and several diseases,including diabetes, has been reported. NOD/ShiLtJ mice are a mod-el for autoimmune type 1 diabetes. The aim of the present work isto study the effect of chronic stress in diabetes development andto characterize the microbiota alterations in NOD/ShiLtJ mice. Forthis purpose, the animals were subject to chronic stress (CS) bythe application of aleatory and unpredictable stressors. NOD/ShiLtJmice exposed to CS (NOD + CS) showed an increase in diabetesincidence (Long-rank test, p