Opposite roles of D1 and D5 dopamine receptors in locomotion revealed by selective antisense oligonucleotides.

DZIEWCZAPOLSKI G, MENALLED LB, GARCÍA MC, MORA MA, GERSHANIK OS, RUBINSTEIN M

NEUROREPORT

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 1998 vol. 9 p. 1 - 5

0959-4965

Contralateral rotations induced by the D1-like agonist SKF 38393 in unilaterally 6-hydroxydopamine-lesioned rats were completely prevented by the administration of the D1-like antagonist SCH 23390. A similar result was obtained after intracerebroventricular administration of an antisense oligodeoxynucleotide for the D1 receptor (D1R-as). Contrariwise, administration of a D5R-as potentiated the effects of SKF 38393, showing a 60% increase in the rotational scores. Both effects were reversible upon cessation of D1R-as or D5R-as treatment and were also specific since rotational scores in rats treated with vehicle or with a randomly designed oligodeoxynucleotide were not modified. These results suggest that whereas D1 receptors play a facilitatory role in locomotion, D5 receptors exert an inhibitory effect.