Executing a spatial task increases neuronal progenitor proliferation in discrete pallial regions of adult zebrafish

MAZZITELLI-FUENTES, LAURA; DELEGLISE, EMILIA; MONGIAT, LUCAS A

Villa Carlos Paz

Congreso; 34 Reunion Anual Sociedad Argentina de Neurociencias; 2019

Sociedad Argentina de Neurociencias

The teleost's pallium is known to be relatedto cognitive abilities like learning, memory and emotion. Thisregion, as well as the entire encephalon, is subjected to constantremodelling by the addition of new-born neurons. In particular, thelateral pallium (LP) is proposed to be involved in processing spatialinformation, and has been postulated to be an homolog of themammalian hippocampus. However, little is known about the impact ofbehaviour on neural circuit plasticity. In this work, we studied theinvolvement of zebrafish´s pallium in a spatial constancy task byanalyzing neural activation and cell proliferation along therostro-caudal axis. We described the c-fos expression profileand found selective activation of the medio-caudal LP in trainedindividuals when compared to joked controls. Regarding cellproliferation, we also observed that trained fish increases PCNAexpression in two restricted pallial sub-regions: rostral medialpallium (MP) and caudal LP. Insum, we successfully assessed zebrafish cognitive ability in aspatial constancy task, and found an activity-dependent increase inproliferation of neuronal progenitors located in discrete pallialsub-regions. It remains to be explored whether this proliferationraise results in an increase in adult neurogenesis in telencephalicpallium. p { margin-bottom: 0.25cm; line-height: 120%; background: transparent none repeat scroll 0% 0%; }