Adult neurogenesis in the zebrafish telencephalon

ROMÁN, FERNANDA; MARPEGAN, LUCIANO; DELEGLISE, EMILIA; MONGIAT, LUCAS ALBERTO

Villa Carlos Paz

Congreso; 34 Reunion Anual Sociedad Argentina de Neurociencias; 2019

Sociedad Argentina de Neurociencias

One of the principal forms of adult neuronalplasticity is the integration of new neurons into preexisting braincircuits. The study of network remodeling by adult neurogenesisinvolvescomplex relationships between newly-added neurons, preexistingnetworks, and neuronalactivity. Zebrafish is an excellent organism to study the activity-dependenceof network remodeling, since it exhibits numerous cognitive abilitiesand adult neurogenesis occurs throughout their brain. In this work wetrained adult zebrafish to achieve an Active Avoidance task. Trainedindividuals show a daily improvement in their avoidance responsesduring 4 consecutive sessions. Moreover, the trained zebrafishexhibits a long term memory of the task, evaluated 24 hours after thelast training session. To address the role of cognitive activity innetwork remodeling we evaluated neuronal progenitors proliferation inthe zebrafish pallium. We found that active avoidance traininginduces a two-fold increase in the proliferation of neuronalprogenitors in a discrete sub-region of the Dorso-medial pallium.This finding leads us to plan further experiments to interrogate therole of this cognitive activity on other aspects of adultneurogenesis, as neuronal fate, synaptic integration, and neuronalsurvival.p { margin-bottom: 0.25cm; line-height: 115%; background: transparent none repeat scroll 0% 0%; }