INVESTIGADORES
MONGIAT lucas Alberto
congresos y reuniones científicas
Título:
A switch from integrative to orthogonal input processing by adult-born neurons
Autor/es:
MARÍA BELÉN PARDI; LUCAS A. MONGIAT; ALEJANDRO F. SCHINDER ; ANTONIA MARÍN-BURGIN
Lugar:
Huerta Grande - Cordoba
Reunión:
Congreso; Reunión Anual Sociedad Argentina de Investigación en Neurociencia; 2011
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencia
Resumen:
Immature granule cells (GC) born
in the adult hippocampus present higher excitability than mature GC, and
require weaker inputs to be recruited in response to the activation of afferent
inputs. These properties suggest that while mature GC are presumably more
selective in their responses, immature GC could be recruited by several inputs,
allowing integrations to occur. To study this hypothesis, we worked on
hippocampal slices from adult mice injected with a retrovirus to express RFP in
newborn GC. We monitored GC activity by loading them with the calcium dye OGB-1
AM. Two electrodes were placed to stimulate independent medial perforant path
inputs at different intensities. Under these conditions, the majority of mature
GC responded to only one of the two stimuli, but most immature GC were equally
recruited by both. Blocking GABAergic inhibition increased mature GC input
integration but did not modify immature GC values. Our results suggest immature
GC integrate different sources of information whereas mature neurons process
incoming information in an orthogonal manner. These functions could imply a
specific role of both GC populations in learning and memory, such as temporal
associations and dissociations of spatial and object information.