INVESTIGADORES
LIZARRAGA Leonardo
congresos y reuniones científicas
Título:
HIGH MOLECULAR WEIGHT CHITOSAN-BASED NANOGELS FOR RESEVERATROL DELIVERY
Autor/es:
BUOSI, FS; ALAIMO, A; MARTÍNEZ, KD; DI SANTO, MC; DOMIGUEZ RUBIO, AP; ACEBEDO, SL; GARCÍA LIÑARES, G; SPAGNUOLO, C; LIZARRAGA, L; PEREZ, OE
Lugar:
Buenos Aires
Reunión:
Simposio; Exploring the Froniers of Chemistry: Challenges for 21st Century; 2019
Institución organizadora:
UBA-Universidad Ben-Gurión del Neguév
Resumen:
Oxidative stress plays a pivotal role in ocular diseases. Antioxidants are crucial agents as prophylactic forms; however, considering its lability, nanotechnology becomes an option to enhance its protection, stability, bioavailability, and therapeutic efficacy. Here, we developed and characterized nanogels (NG) based on high molecular weight chitosan (HCS) crosslinked with sodium tripolyphosphate (TPP). Resveratrol (RSV), a potent antioxidant and anti-inflammatory natural bioactive was proposed by us for ocular diseases prevention. Hence, nanoencapsulation in NG would be an optimal strategy for RSV delivery.
