Expanding the toolbox for enantioselective sulfide oxidations: Streptomyces strains as biocatalysts

MASCOTTI, ML; PALAZZOLO, MA; LEWKOWICZ, E; KURINA-SANZ, MB

Biocatalysis and Agricultural Biotechnology

Elsevier B.V

Año: 2013 vol. 2 p. 399 - 402

1878-8181

Sulfide oxidase activity of Streptomyces genus is reported here for the first time. Three Streptomycesstrains were selected as new tools to access to enantioenriched R- and S-dialkyl sulfoxides. The bacterialscreening was carried out using cyclohexyl methyl sulfide as model substrate. Both sulfoxide antipodes were obtained in a one-pot, time-dependent biotransformation employing Streptomyces phaeochromogenes NCIMB 11741 as biocatalyst. Streptomyces flavogriseus ATCC 33331produced mainly theS-enantiomer, while Streptomyces hiroshimensis ATCC 27429 yielded enantiopure R-cyclohexyl methylsulfoxide.