INVESTIGADORES
LANUSSE Carlos Edmundo
capítulos de libros
Título:
Testing Albendazole Resistance in Fasciola hepatica
Autor/es:
ALVAREZ, LUIS IGNACIO; MARTINEZ VALLADARES, MARÍA ; CANTÓN, CANDELA; LANUSSE, CARLOS EDMUNDO; CEBALLOS, LAURA
Libro:
Fasciola Hepatica
Editorial:
Springer Science+Business Media
Referencias:
Lugar: New York; Año: 2020; p. 213 - 220
Resumen:
The egg development test is a useful in vitro tool to detect albendazole (ABZ) resistance in Fasciolahepatica. ABZ is the only flukicidal compound with ovicidal activity. The described test is based on theABZ capacity to affect parasite egg development and hatching in susceptible parasites, while this effect islost in ABZ-resistant liver fluke isolates. Among many advantages, it is noted that the diagnostic test can beperformed on eggs isolated from fecal samples (sheep and cattle), avoiding the sacrifice of animals necessaryin controlled efficacy trials. The egg development test described here is a simple, inexpensive, and accessiblemethod, previously employed for diagnosis of ABZ resistance in F. hepatica.
