Macrocyclic lactones: endectocide compounds

LANUSSE, C; LIFSCHITZ, A; IMPERIALE, F

Veterinary Pharmacology & Ther.- 10th Edition

Wiley - Blackwell

Lugar: Denver; Año: 2018;

The avermectins and milbemycins are closely related 16-membered macrocyclic lactones (ML), produced through fermentation by soil dwelling actinomycetes (Streptomyces). It was the unique combination killing of endo- and ectoparasites that gave rise to the embracing name ´endectocide? by which the MLs are recognised. The purpose of this Chapter is to provide an updated and integrated overview of the main basic pharmacological features of the ML compounds, which account for their outstanding long-persistence broad-spectrum antiparasitic activity. The MLs are now considered the most widely used broad-spectrum antipararasitic drugs in Veterinary Medicine.