Controversial role of inhibin alpha-subunit gene in the aetiology of premature ovarian failure (POF).

SUNDBLAD V; CHIAUZZI V; ANDREONE L; CAMPOS S; CHARREAU E; DAIN L.

HUMAN REPRODUCTION

OXFORD UNIV PRESS

Año: 2006 vol. 21 p. 1154 - 1160

0268-1161

BACKGROUND: Premature ovarian failure (POF) is characterized by hypergonadotrophic amenorrhoea before the age of 40. Inhibin -subunit (INH-) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. METHODS: Polymorphism ?16 C>T of INH- gene were studied in 61 POF patients and 82 controls above 40 years old (C>40). Substitution 769G>A were studied in 59 POF patients, 76 C>40 and 73 controls below 40 years old (C40 (OR= 1.46; IC 95%= 0.63-3.19). Implication of -16C>T polymorphism in serum inhibin levels was analysed in 46 controls, and no significant differences (p>0.05) were found between CC and CT+TT genotype groups when comparing either mid-follicular phase Pro-C and Inhibin B values or mid-luteal phase Pro-C and Inhibin A values. Heterozygocity for substitution 769G>A was found in 1/59 POF woman, 2/76 C>40 and 6/73 CT and 769G>A variants in INH- gene may not be associated to POF disease.