Role of polymorphisms 919A>G and 2039A>G of FSH receptor (FSHR) gene in premature ovarianfailure (POF) development

V. SUNDBLAD; V. A. CHIAUZZI; L. ANDREONE; S. CAMPO; E. H. CHARREAU; L. DAIN

CURRENT TRENDS IN ENDOCRINOLOGY

MINU JOSEPH EXECUTIVE EDITOR

Año: 2010 vol. 4 p. 21 - 27

0972-947X

Although the impact of polymorphisms 919A>G and 2039A>G of FSHR gene in normal ovarian function is almost clear, in Premature Ovarian Failure (POF) it still remains elusive. To analyse the putative association of these polymorphisms with POF development, 97 POF patients and 72 women over 40 years of age with normal menstrual record were genotyped for 919A>G and 2039A>G variants. No association was found between genotype GG of each polymorphism and the risk of POF. Nevertheless, ten POF patients and only one control presented the less common combinations 919G-2039A and 919A-2039G (p