INVESTIGADORES
JURI AYUB Maximiliano
artículos
Título:
Iridoids as allelochemical and DNA polymerase inhinitors
Autor/es:
CARLOS R. PUNGITORE; MAXIMILIANO JURI AYUB; MATÍAS GARCÍA; EDUARDO J. BORKOWSKI; MARTA E. SOSA; GLADYS CIUFFO; OSCAR S. GIORDANO; CARLOS E. TONN
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
American Chemical Society
Referencias:
Año: 2004 vol. 67 p. 357 - 361
ISSN:
0163-3864
Resumen:
Growth inhibitory activities and nutritional indices of catalpol (compound 1), 8-O-acetylharpagide (compound 2), and harpagide (compound 3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a ð-ð charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
