Effect of H1N1 Neuraminidase Mutations in the Binding Mode of Know Antiviral Compounds

ESTEBAN VEGA-HISSI; LUCAS GUTIERREZ; MATIAS ANDRADA; MARIO R. ESTRADA; JUAN C. GARRO MARTINEZ

Carlos Paz, Argentina

Congreso; 13º Conferencia Latinoamericana de Físico Química Orgánica; 2015

The pandemic nature of the influenza viruses and its ability to rapidly mutate present a serious public health concern and emphasize the importance of developing new and effective anti-influenza drugs.There are two main glycoproteins on the surface of influenza virus particles, hemagglutinin (HA) and neuraminidase (NA). Due to its essential role in limiting the progression of influenza virus infection in the host and its relatively well-conserved active sites, NA has become an attractive target for structure-based antiviral drug development [1].Oseltamivir(OTV) is the best known NA inhibitor which play a vital role in controlling epidemics and pandemics. The emergence of OTV-resistant NA [2] indicates that understanding the molecular mechanism of drug resistance is essential to the development of new NA inhibitors.