INVESTIGADORES
MONTSERRAT Javier Marcelo
artículos
Título:
Confined Gold Nanoparticles Enhance the Detection of Small Molecules in Label Free Impedance Aptasensors.
Autor/es:
ANA S. PEINETTI; HELENA CERETTI; MARTÍN MIZRAHI; GRACIELA ALICIA GONZALEZ; SILVANA A. RAMÍREZ; FÉLIX REQUEJO; JAVIER MONTSERRAT; FERNANDO BATTAGLINI
Revista:
Nanoscale
Editorial:
Royal Society of Chemistry
Referencias:
Lugar: Londres; Año: 2015 vol. 7 p. 7763 - 7769
ISSN:
2040-3364
Resumen:
Acontrolled architecture of nanoelectrodes, with a similar size to smallmolecule-binding aptamers, is synthetized inside nanoporous alumina. Goldnanoparticles are electrogenerated in the alumina cavities showing a fastelectron transfer process toward ferrrocyanide. These caped-free nanoparticlesare easily modified with a thiol-containing aptamer for the label-freedetection of adenosine monophosphate by electrochemical impedance spectroscopy.Our results show that the use of a limited electrical conducting surface insidean insulating environment can be very sensitive to conformational changes,introducing a new approach to the detection of small molecules exemplified hereby the direct and selective detection of adenosinemonophosphate in the nanomolar scale.
