EFFECTS OF 3-ISOPROPYL-4-METHYL-5,7-DIHYDROXYCOUMARIN ON EXPRESSION AND LOCALIZATION OF HSPB1 AND PROTEINS RELATED TO TUMOR PROGRESSION

CAYADO-GUTIÉRREZ, N.; CORDOBA, M.E.; PENNACCHIO, G.E.; DE PAOLA, M.; CUELLO-CARRIÓN, F.D.; FANELLI, M.A.; CIFUENTE, DIEGO A.; PUNGITORE, C.R.; CIOCCA, D.R.

Congreso; XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2019

HSPB1 (HSP27) is a heat shock protein strongly related to cancer; this protein participates in many events associated with tumor progression and resistance to anticancer treatments. The study involves breast cancer, cervical cancer and glioma cells exposed to 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (C13), a semi-synthetic coumarin previously characterized with inhibitory activity of replicative process that could be considered an attractive target in cancer studies