INVESTIGADORES
CAVASOTTO Claudio Norberto
artículos
Título:
Homology modeling in drug discovery: current trends and applications
Autor/es:
CAVASOTTO, CLAUDIO N.; PHATAK, SHARANGDHAR S.
Revista:
DRUG DISCOVERY TODAY
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2009 vol. 14 p. 676 - 683
ISSN:
1359-6446
Resumen:
As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this contribution, we report the current developments in this field, discuss in silico modeling limitations, and review the successful application of this technique to different stages of the drug discovery process.
