DIETARY SOY PROTEIN IMPROVES ADIPOSE TISSUE DYSFUNCTION BY MODULATING PARAMETERS RELATED WITH OXIDATIVE STRESS IN DYSLIPIDEMIC INSULIN-RESISTANT RATS

ILLESCA PG; ALVAREZ SILVINA MONICA; SCELENSIG DA; FERREIRA MR; GIMENEZ MS; ´DÁLESSANDRO ME

BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE.

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Paris; Año: 2017 vol. 88 p. 1008 - 1015

0753-3322

The present study investigates the benefits of the dietary intake of soy protein on adipose tissuedysfunction in a rat model that mimics several aspects of the human metabolic syndrome. Wistar ratswere fed a sucrose-rich diet (SRD) for 4 months. After that, half of the animals continued with SRD untilmonth 8 while in the other half, casein protein was replaced by isolated soy protein for 4 months (SRD-S).A reference group consumed a control diet all the time. In adipose tissue we determined: i) the activitiesof antioxidant enzymes, gene expression of Mn-superoxide dismutase (SOD) and glutathione peroxidase(GPx), and glutathione redox state ii) the activity of xanthine oxidase (XO), ROS levels and the geneexpression of NAD(P)H oxidase iii) the expression of the nuclear factor erythroid-2 related factor-2 (Nrf2).Besides, adiposity visceral index, insulin sensitivity, and tumor necrosis factor-a (TNF-a) in plasma weredetermined. Compared with the SRD-fed rats, the animals fed a SRD-S showed: activity normalization ofSOD and glutathione reductase, improvement of mRNA SOD and normalization of mRNA GPx withoutchanges in the expression of the Nrf2, and improvement of glutathione redox state. These results wereaccompanied by a normalization of XO activity and improvement of both the ROS production as well asTNF-a levels in plasma. Besides, adipocyte size distribution, adiposity visceral index and insulinsensitivity improved. The results suggest that soy protein can be a complementary nutrient for treatingsome signs of the metabolic syndrome.