Role of different protein sources in the morphology of Cd intoxicated lungs

BOLDRINI G; MARTIN MOLINERO G; CIMINARI E; PEREZ CHACA MV; BIAGGIO VS; MOYANO MF; GIMENEZ MS; GOMEZ NN; ALVAREZ SM

Congreso; Sociedad Argentina de Investigacion Clinica; 2018

Sociedad Argentina de Investigacion Clinica

Cadmium (Cd) is a toxic metal and an important environmental contaminant. We studied its effects on morphology, bronchoalveolar lavages (BAL) and LDH activity under different diets. 4 lots of female Wistar rats were used: 2 lots received casein (Cas) and 2 lots received soybean (Soy) as protein sources. Within each group: 1 lot received regular water (control-Co) and the other 15ppm of Cd in the drinking water for 60days. BAL was performed, LDH activity was measured and cells obtained were analysed. Lungs were fixed, sectioned, stained, examined for evidence of injury and analyzed morphometricaly. A lung section was mineralized and cadmium concentration was measured by ICP-MS.Cadmium concentration was higher in intoxicated groups, but only significative in Cas-Cd (p