INVESTIGADORES
BIAGGIO Veronica Silvina
congresos y reuniones científicas
Título:
EFFECTS OF CASTRATION ON CITOPROTECTIVE GENES AND APOPTOTIC MECHANISMS IN RAT LUNG
Autor/es:
BIAGGIO VS; ALVAREZ OLMEDO D; PIGUILLEM S; PEREZ CHACA MV; GIMENEZ MS; GOMEZ NN
Reunión:
Congreso; SOCIEDAD DE BIOLOGIA DE CUYO; 2012
Resumen:
There is strong evidence that oxidative stress plays a key role in the
pathophysiology of several lung diseases. The presence of specific
androgens and estrogen receptors in the lung implies that sex hormones
play a physiological role in pulmonary function. The present
study was designed to determine whether castration and androgen
replacement result in changes in the lung histoarchitecture. Wistar
male rats (200± 20 g) were separated in three groups: controls (Co),
castrated (Ca), and castrated replaced with testosterone (Ca+T) and
sacrificed 30 days after castrations. For light microscopy, the tissues
were fixed and each antibody was assayed in at least three
sections of each lung. ANOVA was used for statistical analysis.
The results indicate that Hsp 27 immunostaining decreased in Ca
group (p