Comparative study of Tilia x viridis extract and isolated compounds on the proliferation of two lymphoma cell lines.

PATRICIA MICUCCI; PAOLA DI LEO LIRA; GABRIELA ZETTLER; SEBASTIAN TURNER; GRACIELA FERRARO; ROBERTO DAVICINO; CLAUDIA ANESINI

Molecular Medicinal Chemistry

INSTITUTO DE INVESTIGACIÓN DE LAS CIENCIAS EXACTAS FÍSICAS Y NATURALES

Lugar: Buenos Aires; Año: 2010 vol. 21 p. 53 - 59

1666-888X

Several lymphoma T cell lines differ in membrane superficial markers and do not respond to the same drugsand compounds. Tilia x viridis (Bayer) Simonk nothosubspecie moltkei (Dippel) Xifreda is a plant widelydistributed in Argentina. The aim of this work was to study comparatively the effects of dichloromethaneextract and isolated compounds on BW 5147 and on another T lymphoma cell line EL-4, evaluatingprincipally proliferation and viability. On BW 5147 cells, dichloromethane extract exerted antiproliferativeaction, presented cytostatic effect at low concentrations and cytotoxic action at high concentrations.Monoterpenes exerted antiproliferative action being the most potent limonene; low concentrations of themwere cytostatic and high concentrations were cytotoxic. On EL-4 lymphoma, dichloromethane extract andmonoterpenes exerted proliferative action, and none of them affected cell viability. It is extremely importantto note that depending on tumor cell type the same extract or compounds can elicit different actions.