Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation.

ROBERTO DAVICINO; MARÍA G MANUELE; GRACIELA FERRARO; BLAS MICALIZZI; CLAUDIA ANESINI

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Taylor & Francis Group.

Lugar: London; Año: 2009 vol. 31 p. 130 - 139

0892-3973

BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H2O2 was related to the activation of the ERK and P38 pathway, NO production and apoptosis. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Drugs capable of producing an increase in H2O2 levels could be used in cancer.