Modulation of neutrophil migratory pattern after immune complex stimulation

GORLINO CV; HARMAN MF; RANOCCHIA RP; GARCÍA IA; MORÓN G; MALETTO BA; HEERINGA P; PISTORESI-PALENCIA MC

Mar del Plata

Congreso; LX Reunión Científica Anual de la Sociedad Argentina de Inmunología; 2012

Sociedad Argentina de Inmunología

Neutrophils recruited from the blood to inflammatory sites are key contributors to the nature of an immune response; however, their presence in chronic inflammatory sites, such as in immune complex (IC)-mediated autoimmune diseases, can be pathogenic. In this study we wanted to determine if IC-stimulation could modulate the expression of migratory molecules and receptors and, hence, drive neutrophil migration. We showed that after in vitro OVA/anti-OVA IC stimulation, murine neutrophils downregulated twofold the surface expression of CD62L (p