CIBICI 14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
New insights in the generation and antitumoral effects of Ag-inexperienced memory CD8+ T cells
Autor/es:
VIANO MARIA ESTEFANIA; BAEZ NATALIA; SAVID FRONTERA C; MARIA CECILIA RODRIGUEZ GALAN
Lugar:
Tucumán
Reunión:
Congreso; LXVII Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI); 2019
Institución organizadora:
Sociedad Argentina de Inmunología (SAI)
Resumen:
Ag-inexperienced memory CD8+ T cells (AIM) are a subset of T lymphocytes with particular phenotypic features (CD44hi CD122hi CD49dlo Eomeshi Tbetlo) and the ability to rapidly produce IFN after IL-12+IL-18 stimulation. An antitumor role of AIM has been recently postulated both in mice and in humans. Our experiments using murine tumor cell lines demonstrate that systemic expression of IL-12+IL-18 in OT-I mice (by hydrodynamic injection of its cDNAs) significantly increased the number of AIM in SLO (spleen and lymph nodes) and attenuates tumor growth compared to control group (injected with an empty cDNA)(p
