INVESTIGADORES
FUSCO luciano Sebastian
artículos
Título:
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom by Polyvalent Bothropic antivenoms produced in the Northeast of Argentina
Autor/es:
RODRÍGUEZ JUAN PABLO; GAY C.; FUSCO LUCIANO SEBASTIAN; GAUNA M.C; ACOSTA DE PÉREZ, O.; LEIVA LAURA
Revista:
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
Editorial:
CEVAP-UNESP
Referencias:
Año: 2012 vol. 18 p. 116 - 123
ISSN:
1678-9199
Resumen:
Abstract: Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations.
