Hsp90-Binding Immunophilins as a Potential New Platform for Drug Treatment

ERLEJMAN A.G; LAGADARI M.; GALIGNIANA M.D.

Future Medicinal Chemistry

Future Science Group

Lugar: London; Año: 2013 vol. 5 p. 591 - 607

1756-8919

Immunophilins are proteins that contain a peptidyl-prolyl-(cis/trans)-isomerase domainas a family signature. Low molecular weight immunophilins were first described associated to immunosuppressive action and protein folding. Recent studies of other members of the family have led to the identification of their participation in basic processes such as protein-protein interactions, signal transduction cascades, cell differentiation, cell cycle progression, metabolic activity, apoptosis mechanisms, microorganisms infection, cancer, neurotrophism and neuroprotection, among several other physiological and pathophysiological processes. Due to all these emerging features, the developing of specific ligands for immunophilins appears to have promising perspectives during the following years, in particular in the cancer biology and neuroregeneration fields. In this article we discuss the emerging role of immunophilins in protein transport, transcription regulation, malignancies development, and neurotrophic action, a number of biologicalproperties that transforms these proteins in potential targets for novel therapeutic strategies. peptidyl-prolyl-(cis/trans)-isomerase domainas a family signature. Low molecular weight immunophilins were first described associated to immunosuppressive action and protein folding. Recent studies of other members of the family have led to the identification of their participation in basic processes such as protein-protein interactions, signal transduction cascades, cell differentiation, cell cycle progression, metabolic activity, apoptosis mechanisms, microorganisms infection, cancer, neurotrophism and neuroprotection, among several other physiological and pathophysiological processes. Due to all these emerging features, the developing of specific ligands for immunophilins appears to have promising perspectives during the following years, in particular in the cancer biology and neuroregeneration fields. In this article we discuss the emerging role of immunophilins in protein transport, transcription regulation, malignancies development, and neurotrophic action, a number of biologicalproperties that transforms these proteins in potential targets for novel therapeutic strategies.