Chlorpyrifos promotes the migration of breast cancer cells activating c-SRC, AKT, GSK-β and p38 pathways

LASAGNA, M.; VENTURA, C; HIELPOS, M.S.; MARDIROSIAN, M.N.; MIRET, N.; RANDI, A.; NUÑEZ, M; COCCA, C.

Congreso; LXV Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2020

Chlorpyrifos (CPF) is a pesticide whose effects on breast cancer risk are not clear. Our aim was to analyze if CPF promotes migration and the pathways involved in MCF-7 and MDA-MB-231 cell lines. Migration was evaluated by 2D (wound healing and Boyden Chamber assays) and 3D assays (multicellular spheroids). c-Src, AKT, P38 and GSK3-β were studied by Western Blot. In MCF-7 cells, 0.05 µM CPF induced the migration after 48 h (p