Model of avascular tumor growth and response to low dose exposure

JUAN MANUEL RODRÍGUEZ AGUIRRE; ERNESTO R. CUSTIDIANO

Journal of Physics: Conference Series

IOP SCIENCE

Año: 2011 vol. 332

A single level cellular automata model is described and used to simulate early tumor growth, and the response of the tumor cells under low dose radiation aects. In this model the cell cycle of the population of normal and cancer cells is followed. The invasion mechanism of the tumor is simulated by a local factor that takes into account the microenvironment hardness to cell development, in a picture similar to the AMTIH model. The response of normal and cancer cells to direct eects of radiation is tested for various models and a model of bystander response is implemented.