Mass spectra studies of diamide compounds obtained by Ugi reaction

RETA, G. F.; CECATI, F. M.; TERUEL, N. A.; ROSSOMANDO, P. C.; DONADEL O. J.; MARTIN, V. S.; TONN, C. E.; KURINA-SANZ, M. B.; ARDANAZ, C.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY : RCM.

JOHN WILEY & SONS LTD

Lugar: Londres; Año: 2013 vol. 27 p. 2033 - 2038

0951-4198

A couple of potential bioactive diamides derived from cinnamic were prepared by the Ugi multicomponent reaction. In order to identify them and their possible metabolites in complex biological matrices, the study of their fragmentation routes has been carried out by LR-EIMS, EI-CID-MSn, and HR-EIMS. The genesis of the main fragments was achieved by using GC/EI-CID-MSn. In addition, the employment of EIHRMS allowed us to measure the exact masses of all the fragment ions, and assure the fragmentation schemes that were established in agreement with the structural determination achieved by NMR data.