METABOLIC RISK FACTORS TO RENAL STONE FORMATION IN CHILDREN

MOYANO F, ; ORELLANO G, ; WENDEL G, ; FUENTES L

Mendoza

Congreso; XXXI Reunión Científica Anual Sociedad de Biología de Cuyo; 2013

SOCIEDAD DE BIOLOGÍA DE CUYO

Physiological disturbances may create an environment conductive to renal stone formation. The aim was to evaluate metabolic risk factors to renal stones formation in children. In this retrospective study, we evaluated a total of 431 individuals using a standardized protocol and our pediatric patient was 11.60%. Urine (24h, 2h) and blood were recollected. Calcium, phosphorus, creatinine, magnesium, urea, uric, citric and oxalic acid, parathormone, sodium and potasium were determined. Mean age: 11.54±0.68 years old, male:female ratio 25:25, BMI: 18.89±0.81. Prevalence of obesity was 12%, overweight 8% and under-nutrition 20% (WHO,2007). Biochemical abnormalities were found in 96% of individuals. Multiple risk factors were present in 92% (n=47) of the patients, and a single urine metabolic risk factor was present in the remaining 8% (n=3). Idiopathic hypercalciuria 54% (alone or in combination), hypocitraturia and hypomagnesuria 80% (alone or in combination), oxaluria 64% and uricosuria 44% were the most frequent risk factors identified. Marginal hypercalciuria 32% (most 12 years). The evaluation of metabolic risk factor in children to renal stone disease is the basis of medical treatment aimed at preventing recurrent stone events and the growth of preexisting calculi. We conclude that specific urine metabolic risk factors are found in most children with kidney stones and that hypocitraturia is as frequent as hypercalciuria.