Antibacterial screening of a coumarines group

MASCOTTI, ML; GARRO, HA; PUNGITORE, CR; TONN, CE; KURINA-SANZ, MB; GIANNINI, FA

San Luis

Otro; XXVII Reuncion cientifica anual de la sociedad de biología de cuyo; 2009

Coumarines are plant ubiquitous compounds fully distributed in families such as in Umbelliferae/Apiaceae and Rutaceae. They have been isolated as glycosides and/or in their free forms. It has been reported for them antifungal, antibacterial and, the most well-known, anticoagulant activity, the last one involved in defense mechanisms against predators. The objective of this work was to evaluate antibacterial activity of 5-hidroxycoumarin (1), 3-acylcoumarin (2), coumaranone (3), 4-hidroxycoumarin (4), coumarin (5), 3-hidroxycoumarin (6), 7- hidroxycoumarin (7), 6-hidroxycoumarin (8), against Lactobacillus acidophilus, Bifidobacterium bifidum and Bacillus subtilis, from a commercial liophilyzated of gram+ bacterium, by micro-dilution agar assay