Bioactivity-Acute toxicity test using as experimental model bacteria

MASCOTTI, ML; BISOGNO, FR; KURINA-SANZ, MB; GIANNINI, FA

San Luis

Otro; XXIV Reunion ceintifica anual sociedad de biología de cuyo; 2006

The  potential  bioactivity  of  a  compound  can  be associated with it’s toxicity, taking into account the noxious effect that drugs presents toward living organisms. This evaluation can be done using multicellular organisms as crustaceans, rotifers, fishes, amphibians  and  even  for more  advanced  studies mammalian; but those  assays  are  very  expensive,  requires  important  quantities  of drugs  and  even  are  very  conflictive  because  of  animals  law’s protection.   We present  in  this work  the development of  a bioassay requiring  bacteria  as  experimental  model,  specifically Lactobacillus  acidophilus  and  Bacillus  subtilis.  Commercial lyophilized bacteria are suitable for this assay.