PERSONAL DE APOYO
MANZUR Maria jimena
artículos
Título:
Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
Autor/es:
GARRO HUGO; MANZUR JIMENA; CIUFFO GLADYS; TONN CARLOS; PUNGITORE CARLOS
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 24 p. 760 - 764
ISSN:
0960-894X
Resumen:
Coumarin derivatives were prepared using natural products isolated from plants belonging in thePterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activityagainst myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 producedinhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase(analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Suchinhibitors may have importance as antiretroviral chemotherapeutic agents and also in the developmentof anticancer drugs.
