Antimetastatic effect of the penicillin derivative TAP6 in melanoma cells

BARRIONUEVO E; CORNIER P.G.; DELPICCOLO CM; BOGGIÁN D.B; MATA E.G.; ROGUIN LP; BLANK VC

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

SAIC. SAI. SAFE. SAA. SAIB. SAB. SAFIS.SAP. SAH

Metastatic dissemination of cancer cells is the main cause of death in melanoma patients. In the search of new antimetastatic compounds, in a previous work, we found that the penicillin derivative named TAP6, formed by a penicillin linked to the dipeptide Phe-Leu through a triazole group, inhibited adhesion and migration of B16F10 metastatic murine melanoma cells. In order to continue studying the antimetastatic properties of TAP6, we investigated the effect of the penicillin derivative on B16F10 cells invasion. Transwell invasion assay results demonstrated that a 10 µM concentration of TAP6 inhibited cell invasion after 18 h treatment (96.1±0.4%, p