Hyperthermic triggers for drug delivery platforms

ALARCON SEGOVIA, LILIAN C.; MOREL, MARIA ROSARIO; DAZA-AGUDELO, JORGE IVAN; ILARDO, JUAN CARLOS; RINTOUL, IGNACIO

NANOTECHNOLOGY

IOP PUBLISHING LTD

Año: 2023

0957-4484

Electromagnetic fields can penetrate aqueous media in a homogeneous and instantaneousway, without physical contact, independently of its temperature, pressure, agitation degreeand without modifying their chemical compositions nor heat and mass transfer conditions. Inaddition, superparamagnetic biomaterials can interact with electromagnetic fields byabsorbing electromagnetic energy and transforming it in localized heat with further diffusionto surrounding media. This paper is devoted to the exploration of the potential use ofhyperthermic effects resulting from the interaction between externally appliedelectromagnetic fields and superparamagnetic nanoparticles as a trigger for controlled drugrelease in soft tissue simulating materials. Gelatin based soft tissue simulating materials wereprepared and doped with superparamagnetic nanoparticles. The materials were irradiated withexternally applied electromagnetic fields. The effects on temperature and diffusion of a drugmodel in water and phosphate buffer were investigated. Significant hyperthermic effects wereobserved. The temperature of the soft tissue simulating material resulted increased from 35°Cto 45°C at 2.5 °C/min. Moreover, the release of an entrapped model drug reached 89%. Theintensity of the hyperthermic effects was found to have a strong dependency on theconcentration of superparamagnetic nanoparticles and the power and the pulse frequency ofthe electromagnetic field.