Hybrid Thermosensitive-Nanogels based on N-vinylcaprolactam

ANA S. SONZOGNI; VERÓNICA GONZALEZ; SANTIAGO VAILLARD; MARIO PASSEGGI; LUIS GUGLIOTTA; ROQUE MINARI

Porto de Galinhas

Simposio; XIV Latin American Symposium on Polymers; 2014

Brazilian Polymer Association

This work presents a semibatch strategy to produce hybrid nanogels with core-shell morphology. The synthesized nanogels have a core of poly(N-vinylcaprolactam) (PVCL), a biocompatible polymer with a phase transition closed to the physiological temperature, and a shell of poly(butyl acrylate) (PAcBut) that provides the properties of adhesiveness and film formation. This nanogels could be directly used in transdermal drug release, without requiring a support and adhesive matrix. Morphology, particle diameter and thermal response of the nanogels were evaluated along the work.