Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) elastomers for the sustained release of Paclitaxel

LUCILA NAVARRO; ROQUE MINARI; NATALIA CEAGLIO; MARIANELA MASIN; SANTIAGO VAILLARD

Journal of Polymer Science Part A: Polymer Chemistry

wiley online library

Año: 2018 vol. 56 p. 1199 - 1209

1099-0518

Over the past ten years poly-(polyol alkanoate)s elastomers have intensively been investigated dueto their extraordinary potential for soft tissue engineering applications. In this work, a family of novelhyper-branched elastomers based on pentaerytrhritol and adipic acid, modified with PEG of 200 and400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoidsthe use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting themolar ratio of monomers and curing conditions. The elastomers, which are fully characterized bystandard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell cultureassays indicate that all materials are able to inhibit lung cancer cell proliferation and that the releaseof Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are goodcandidates for their use as eluting systems in long term cancer treatment