Osteoporosis, an approach of treatment via chitosan-beta-glycerophosphate-fluoride gesl

FEDERICO A. FOOKES; LUCIANO N. MENGATTO; ALFREDO RIGALLI; JULIO A LUNA

Córdoba

Otro; 6ta Reunión Internacional de Ciencias Farmacéuticas; 2021

Universidad Nacional de Córdoba

In recent years, chitosan—glycerophosphate hydrogels have been extensively studied for pharmaceutical application. In the current work, this matrix was tested as a platform for sodium fluoride release in the gastrointestinal tract. Fluoride release was selected due to its well-known use in osteoporosis treatment. For this purpose, microscopy observation, infrared spectroscopy and reological characterization were carried out. In addition, stability studies of the gels and the release profiles of the active principle in different media were studied. In aqueous media with pH between 4 and 7, the systems proved to be stable and to maintain a controlled release of the active principle for more than 6 hours. In order to compare the oral administration of sodium fluoride included in the hydrogel or in a water solution, in vivo studies were performed. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. However, when the active principle was administered with the hydrogel, fluoride absorption was higher and drug-related side effects were absents.In consequence, Chitosan - β-glycerophosphate hydrogels containig sodium fluoride could be considered as a suitable formulation for orally osteoporosis treatment.