Novel controlled release hydrogels formulation based on dendritic anionic polyelectrolyte-ciprofloxacin complexes

MONICA GARCIA; JULIO CÉSAR CUGGINO; RUBEN MANZO; CECILIA I. ALVAREZ IGARZABAL; ALVARO JIMENEZ-KAIRUZ

Rosario

Congreso; 2º Reunión Internacional de Ciencias Farmacéuticas; 2012

Hydrogels are three-dimensional, cross-linked networks of water soluble polymers. A particular class of hydrogels is based on drug-polyelectrolite (D-PE) complexes, where a molecular dispersion of D is ionically bounded at the ionizable groups of PE (1-4). The unique phisical properties of these hydrogels place them as interesting systems to be used en controlled D delivery (5). Recently, a new anionic dendritic polylelectrolyte (DP) was synthesized by aqueous free-radical polymerization of a particularly prepared vinyl monomer derivate from Behera´s amine (6). In previous work, DP was considered as a potential non toxic material (7). Its complexes with Ciprofloxacin (Cip) showed acceptable microbiological activity versus Staphylococcus aureus y Pseudomona aeruginosa (8). This work is based on the evaluation of DP as a carrier of the antimicrobial Cip with potential use in topical and mucosal administration. Cip was selected as ionizable model drug because of its wide use in common topical opportunist infections.