INVESTIGADORES
CUGGINO Julio Cesar
artículos
Título:
Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release
Autor/es:
JULIO C. CUGGINO; CINTIA B. CONTRERAS; ALVARO F. JIMENEZ-KAIRUZ; BELKYS A. MALETTO; CECILIA I. ALVAREZ IGARZABAL
Revista:
MOLECULAR PHARMACEUTICS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2014 vol. 11 p. 2239 - 2249
ISSN:
1543-8384
Resumen:
The synthesis, characterization and properties of pH / thermo-sensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N′-diallyltartramide (DAT) as crosslinking agent and water as solvent, are presented in this paper. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.
