A Facile, Selective Preparation of Monoketals from Pentaerythritol and Ketones

MARCELO C. MURGUÍA, SANTIAGO E. VAILLARD AND RICARDO J. GRAU

SYNTHESIS

Gerog Thieme Verlag stuttgart

Año: 2001 p. 1093 - 1097

1414-915X

The selective preparation of  monoketals 3a-f from pentaerythritol 1 and cyclic, acyclic, aromatic, and aliphatic ketones 2a-f was achieved by a facile method. The extreme polarity and low solubility of pentaerythritol in allmost all solvents were the mail difficulties to be overcome for the preparation of monoketals in good yields and high selectivity. A benzene-dimethylformamide (40/60) mixture proved to be excellent for the ketalization. The one-step procedure developed allowed the preparation of monoketals in good yield and good to excellent selectivity (higher than 90%)