INVESTIGADORES
VAILLARD Santiago Eduardo
artículos
Título:
Synthesis of Benzene- and Pyridinediboronic Acids via Organotin Compounds
Autor/es:
SANDRA D. MANDOLESI, SANTIAGO E. VAILLARD, JULIO C. PODESTA , Y ROBERTO A. ROSSI
Revista:
ORGANOMETALLICS
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2002 vol. 21 p. 4886 - 4888
ISSN:
0276-7333
Resumen:
1,4- and 1,3-Bis(trimethylstannyl)benzenes as well as 2,5- and 2,6-bis(trimethylstannyl)pyridines react with borane in THF to give intermediates which on hydrolysis lead to benzene- and pyridinediboronic acids in 79-83% yield. While oxidation of the benzenediboronic acids with alkaline hydrogen peroxide gives the corresponding 1,3- and 1,4-dihydroxybenzenes, the pyridinediboronic acids lead via a double Suzuki reaction with 4-iodoanisole to 2,5- and 2,6-bis(4-methoxyphenyl)-pyridines and react with pinacol to give the corresponding pyridine-2,5-pinacol and pyridine-2,6-pinacol diboronic esters.
