Optimization of the mathematical modeling of drug delivery from planar polymeric systems

IGNACIO M. HELBLING; JUAN C. D. IBARRA; DRA. MARÍA I. CABRERA; DR. JULIO A. LUNA

Mar del Plata

Congreso; XVIII Congreso Argentino de Bioingeniería: 2º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos; 2011

Analytical solutions for the case of dispersed–drug controlled release from non–erodible planar matrices, based on Refined Integral Method, are presented. A new adjusting equation is used for the dissolved drug concentration profile in the depletion zone of the matrix. In order to illustrate the validity and usefulness of the model, comparisons with experimental profiles reported in the literature are presented. A close match between the model predictions and the experimental data is observed. In addition, a comparison with a model reported previously by others authors is also presented. The results show that our model has a better performance than the previously reported equations in the prediction of the experimental release profiles. As conclusion, the obtained results show that the model can be employed in a broad range of drug delivery systems.