Paclitaxel delivery system based on poly(lactide-coglycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment

JUAN I. PESOA; DR. JULIO A. LUNA; LUCIANO MENGATTO

AFRICAN JOURNAL OF ECOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2018

0141-6707

Objectives To evaluate the combination of more than one release system in thesame formulation as a useful strategy to achieve paclitaxel delivery in a more sustainedand controlled manner.Methods The present study deals with the preparation of poly(lactide-co-glycolide)microparticles loaded with paclitaxel and included in a chitosan thermosensitivegelling solution. The microparticles were characterized by their size,shape and drug loading. The formulation was characterized by scanning electronmicroscopy, in vitro release experiments and was evaluated in mice bearingmammary adenocarcinoma.Key findings The formation of paclitaxel crystals in a pharmaceutical formulationreduces its efficacy. In this work, the use of microparticles avoided this phenomenon.Combining more than one delivery system allowed deliveringpaclitaxel in a more sustained and controlled manner leading to a long-termeffect in the site of action. The formulation showed an inhibition in tumourvolume of 63.0% in comparison with the control group.Conclusions One intratumour injection of gelling solution containing the microparticleswas at least as efficacious as four intraperitoneal injections of a commercialformulation. In addition, the delivery system was nontoxic, and the treated micepresented the highest percentage of tumour regression and median survival time.