In vitro evaluation of suspoemulsions for in situ-forming polymeric microspheres and controlled release of progesterone

L. N . TURINO; R.N. MARIANO,; LUCIANO NICOLÁS MENGATTO; DR. JULIO A. LUNA

JOURNAL OF MICROENCAPSULATION

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2015

0265-2048

One possibility to obtain a higher dose of drug in a lower formulation volume can be by usingof saturated quantity of drug in one of the phases of an emulsion. These formulations are calledsuspoemulsions (S/O/W). When a hydrophobic polymer is added to the organic phase ofsuspoemulsions, these formulations can be used to entrap the drug inside microspheres afterin situ precipitation of the polymer?drug?excipients mix. In this work, performance and stabilityof progesterone suspensions in triacetin as organic phase of suspoemulsions were evaluated.These formulations were compared with O/W emulsions. Mathematical models were used tostudy in vitro release profiles. The results confirmed that S/O/W systems could be an attractivealternative to O/W formulations for the entrapment of progesterone inside poly(D,L-lactide-coglycolide)microspheres. Diffusive-based models fit the in vitro release of progesterone fromin situ-formed microspheres. For longer release periods, a time-dependent diffusion coefficientwas successfully estimated.