Preformulation study in commercial powder of Valeriana officinalis L. root

ARCE, SILVIA; ORTEGA, CLAUDIA; FUSCO, MARIA; ACOSTA, GIMENA; MARTINEZ, LUIS DANTE; GOMEZ, MARÍA ROXANA

San Luis

Congreso; XXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2007

Sociedad de Biología de Cuyo

Valeriana officinalis L. “Valeriana” a native plant from Europe and Asia is used for its sedative activity. In this work the pharmacognostic study of a commercial powder from “Valeriana” roots is presented (microscopic assay and identification reactions). In addition, the compactation properties (compressibility and compactibility) of the powder were studied with the aim of achieving a suitable solid dosage form. The commercial powder was analyzed microscopically. The hydroalcoholic solid residue was adsorbed over an inert excipient (fumed silica) forming a solid extract (SE). Different tests were carried out to evaluate the powder rheological and physical characteristics. Finally, different tablets formulations were designed and manufactured and the pharmacotechnical tests were performed. The identity of the commercial powder was established by performing microscopic analysis and identification reactions. The SE controls comprised: solid residue assay, density and compressibility assays, angle of repose. The obtained results were appropriate. The powder ability to form coherent compacts was studied by performing the tablet compactation. The rheological properties, hardness, friability, weight uniformity and disintegration were evaluated in the obtained tablets.