Design of oral pharmaceutical forms from Paullinia cupana Mart. seeds

ACOSTA, GIMENA; SOSA, ANGELA; CIANCHINO, VALERIA; MARTINEZ, LUIS DANTE; GOMEZ, MARÍA ROXANA

San Luis

Congreso; XXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2007

Sociedad de Biología de Cuyo

Guaraná, Paullinia cupana Mart. is a native plant from Brasil with widely used seeds because of their medicinal properties. Its seeds possess a high concentration of caffeine, theophylline and theobromine in low quantities, terpenes, flavonoides and tanines as well. In this work the pharmacognostic study of a commercial powder from Guarana seeds is presented; the design of 4 pharmaceutical oral solid dosage forms; a caffeine dissolution assay and 2 determination methods. The commercial powder was analyzed microscopically. The hydroalcoholic solid residue was adsorbed over an inert excipient (fumed silica) forming a solid extract (SE). Different formulations were proposed by using various excipients. The biopharmaceutical behavior of the obtained tablets was studied by performing a dissolution test. The caffeine determination was achieved with 2 different methods: spectrophotometry UV and capillary electrophoresis (CE). The powder authenticity was confirmed by microscopic analysis and identification reactions. The SE exhibited suitable rheological, physical and mechanical properties, making possible the design and tablet manufacture using direct compression technology. The developed CE methodology was adequated for the evaluation of the designed tablets allowing the study of the pharmaceutical dosage forms performance.