INVESTIGADORES
GOMEZ Maria roxana anabel
artículos
Título:
In vitro-in vivo antifungal evaluation and structure-activity relationships of 3H-1,2-dithiole-3-thione derivatives
Autor/es:
GIANNINI, FERNANDO; AIMAR, MARIO; SORTINO, MAXIMILIANO; GOMEZ, MARÍA ROXANA; STURNIOLLO, ALEJANDRO; JUAREZ, AMERICO; ZACCHINO, SUSANA; DE ROSSI, RH; ENRIZ, RICARDO DANIEL
Revista:
IL FARMACO; EDIZIONE PRATICA.
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2004 vol. 34 p. 245 - 254
ISSN:
0014-827X
Resumen:
As part of our project devoted to the search of new antifungal agents, we report here the in vitro?in vivo antifungal evaluations and a structure?activity relationship (SAR) study of 17 thione derivatives.Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.
