Preyssler heteropolyacids encapsulated in a silica framework for an efficient preparation of fluorinated hexahydropyrimidine derivatives in solvent-free conditions

A. G. SATHICQ; D. RUIZ; T. CONSTANTIEUX; J. RODRIGUEZ; G. ROMANELLI

SYNLETT

GEORG THIEME VERLAG KG

Año: 2014 vol. 25 p. 881 - 883

0936-5214

A series of trifluoromethylated hexahydropyrimidines was synthesized using Preyssler heteropoly acid H14NaP5W29MoO110 encapsulated in a silica framework as the catalyst under solvent-free conditions. This synthesis requires short reaction times (1.5 h) and 80 °C under solvent-free conditions to obtain good to excellent yields of 18 hexahydropyrimidine derivatives. Preyssler catalyst embedded in the silica matrix, unlike thebulk or supported on silica, is insoluble in polar media such as acetone,ethanol, or methanol, which allows easy removal of the reaction products without affecting catalytic activity.