Porous modified bentonite as efficient and selective catalyst 4 in the synthesis of 1,5-benzodiazepines

M. MUÑOZ; A. SATHICQ; G. ROMANELLI; SILVINA HERNÁNDEZ; C. CABELLO; I. BOTTO; M. CAPRON

JOURNAL OF POROUS MATERIALS

SPRINGER

Lugar: Berlin; Año: 2013 vol. 20 p. 65 - 73

1380-2224

The synthesis of 1,5 benzodiazepine using natural and modified Argentinean bentonite (pillared layered clay and porous clay heterostructure) as catalysts through a condensation reaction between o-phenylenediamine (o-PDA) and excess of acetone as reactive and solvent at room temperature is reported. The catalysts were found to be highly active and selective, affording a high yield of the corresponding benzodiazepine. The effects of the modification of the natural bentonite and reaction conditions, such as temperature, time and amount of catayst were investigated. The catalysts were also successfully employed for the preparation of other derivatives of 1,5- benzodiazepine using substituted o-PDAs and ketones. In all cases, the reactions are highly selective and are completed within 1–3 h. The catalyst showed excellent activity Bentonite Modified bentonite Catalysis 30 Heterogeneous 1,5-Benzodiazepines