P2W18O62·24H2O as an efficient and recyclable catalyst for the ecofriendly preparation of β-aminocrotonates

L. SANCHEZ; A. SATHICQ; G. BARONETTI; H. THOMAS; G. ROMANELLI

CANADIAN JOURNAL OF CHEMISTRY

NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS

Lugar: Otawa; Año: 2013 vol. 91 p. 137 - 142

0008-4042

H6P2W18O62·24H 2O bulk-and silica-supported catalysts were found to be efficient and recyclable catalysts for the synthesis of a series of ?-aminocrotonates using toluene as the solvent or under no solvent reaction conditions. Several substituted ?-aminocrotonates can be prepared in very good yields and purity by direct reaction of amines and 1,3-dicarbonyl compounds in the presence of a catalytic amount of bulk-and silica-gel-supported H6P 2W18O62·24H2O. The title compounds were prepared in very good yields using both methodologies, and no secondary products were detected. The procedure using no reaction solvent resulted in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, the use of a reusable and noncorrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.